pI: 8.3895 |
Length (AA): 106 |
MW (Da): 12595 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
4 | 105 | 1twf (I) | 6 | 111 | 23.00 | 0 | 0.73 | 1.13 | 0.86 |
53 | 106 | 1qyp () | 2 | 55 | 44.00 | 0 | 0.95 | 0.97 | -0.18 |
3 | 106 | 3h0g (I) | 5 | 112 | 23.00 | 0.000000031 | 0.75 | 1.07293 | 1.43 |
53 | 105 | 1qyp (A) | 2 | 54 | 45.00 | 0.000011 | 0.95 | 0.9798 | 0.25 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | gametocyte, merozoite, sporozoite, early ring, early trophozoite, late ring, late trophozoite. | PlasmoDB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 24 hs, early schizont, late schizont. | Otto TD PlasmoDB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, Ring, Female Gametocyte. | Otto TD Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Oocyst, Sporozoite. | Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | intra-erythrocytic - 48 hs, Male Gametocyte. | Otto TD Lasonder E |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Ortholog group members (OG5_127419)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G07950 | DNA-directed RNA polymerase, subunit M |
Arabidopsis thaliana | AT1G01210 | DNA-directed RNA polymerase, subunit M |
Babesia bovis | BBOV_II000510 | transcription factor S-II protein, putative |
Brugia malayi | Bm1_53520 | DNA-directed RNA polymerases III 12.5 kDa polypeptide, putative |
Candida albicans | CaO19.5360 | DNA-directed RNA polymerase III |
Candida albicans | CaO19.12820 | DNA-directed RNA polymerase III |
Caenorhabditis elegans | CELE_Y77E11A.6 | Protein RPC-11 |
Cryptosporidium parvum | cgd7_510 | RNA polymerase III subunit C11 |
Dictyostelium discoideum | DDB_G0287707 | RNA polymerase III subunit |
Drosophila melanogaster | Dmel_CG33785 | CG33785 gene product from transcript CG33785-RA |
Echinococcus granulosus | EgrG_001094900 | RNA polymerase III |
Entamoeba histolytica | EHI_053450 | RNA polymerase III subunit, putative |
Echinococcus multilocularis | EmuJ_001094900 | RNA polymerase III |
Giardia lamblia | GL50803_137619 | RNA polymerase III subunit C11 |
Homo sapiens | 51728 | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa |
Leishmania braziliensis | LbrM.19.0740 | RNA polymerase III C11 subunit, putative |
Leishmania donovani | LdBPK_190420.1 | DNA-directed RNA polymerase III subunit C11, putative |
Leishmania infantum | LinJ.19.0420 | RNA polymerase III C11 subunit, putative |
Leishmania major | LmjF.19.0420 | RNA polymerase III C11 subunit, putative |
Leishmania mexicana | LmxM.19.0420 | RNA polymerase III C11 subunit, putative |
Loa Loa (eye worm) | LOAG_09878 | DNA-directed RNA polymerase III polypeptide |
Mus musculus | ENSMUSG00000038628 | polymerase (RNA) III (DNA directed) polypeptide K |
Neospora caninum | NCLIV_055830 | hypothetical protein |
Oryza sativa | 4330285 | Os02g0672700 |
Onchocerca volvulus | OVOC2365 |
|
Plasmodium berghei | PBANKA_0304200 | DNA-directed RNA polymerase III subunit RPC10, putative |
Plasmodium falciparum | PF3D7_0206600 | DNA-directed RNA polymerase III subunit RPC10, putative |
Plasmodium knowlesi | PKNH_0414400 | DNA-directed RNA polymerase III subunit RPC10, putative |
Plasmodium vivax | PVX_003760 | transcription factor, putative |
Plasmodium yoelii | PY00068 | Zn-ribbon transcription factor-related |
Saccharomyces cerevisiae | YDR045C | DNA-directed RNA polymerase III core subunit RPC11 |
Schistosoma japonicum | Sjp_0061000 | ko:K03019 DNA-directed RNA polymerase III subunit C11, putative |
Schistosoma mansoni | Smp_034100 | DNA-directed RNA polymerase |
Schmidtea mediterranea | mk4.001125.10 | DNA-directed RNA polymerase subunit |
Trypanosoma brucei gambiense | Tbg972.10.18440 | RNA polymerase III C11 subunit, putative,DNA- directed RNA polymerase III, putative |
Trypanosoma brucei | Tb927.10.15150 | DNA-directed RNA polymerase III subunit C11, putative |
Trypanosoma cruzi | TcCLB.510029.40 | DNA-directed RNA polymerase III subunit C11, putative |
Trypanosoma cruzi | TcCLB.511291.120 | DNA-directed RNA polymerase III subunit C11, putative |
Toxoplasma gondii | TGME49_312250 | DNA-directed RNA polymerase III RPC11 |
Theileria parva | TP04_0529 | hypothetical protein |
Trichomonas vaginalis | TVAG_482170 | DNA-directed RNA polymerase I, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.15150 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.15150 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.15150 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.15150 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
YDR045C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0304200 | Plasmodium berghei | Slow | plasmo |
TGME49_312250 | Toxoplasma gondii | Essentiality uncertain | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.6